Hey, sorry for the late reply.
It's so hard to remember if I got that sorted out. My Bronco has changed SO much since then, and I don't remember which steps of the process changed what.
There were a few things I learned though. Now, I don't know if this is the same with an Edelbrock, but it is with a Holley. Holleys can struggle a bit to give good mpg when you lug them too low. Like, low vacuum at cruise. The reason for this is because the engine, even though it's spinning really slowly, has to push really hard to turn the gears over. I had a 3.00 rear end, the 2.47 is going to be even worse. When it has to push that hard to spin the engine, you're in the power circuit the entire time. With a Holley, this has the power valve constantly open, even at cruise. This'll be dumping fuel. I imagine the Edelbrock has something similar. I've never tuned an Edelbrock so can't say for sure.
Back when I made my original post 11 years ago, I had 31" tires and the SROD transmission. I found out that I would get better mpg in 3rd gear than I would in overdrive. Even though the engine was spinning faster in 3rd, it was working so much less.
When you originally had the 1bbl on there, it doesn't have that kind of enrichment circuit like a power valve, so even though it's tossing in some more fuel, it doesn't toss in that much. So when your engine can't keep the power up, you just lose speed. The 4bbl now can introduce the power, so you maintain speed but use more fuel.
As for the coil, if you're using the stock system, there's a resistance wire that lowers the voltage to the coil to 8 volts. If you have a 12v coil, it's not getting its full voltage. Either remove the resistance wire, or get an 8v coil. That might help a little with your spark.
Lastly, as far as the C vs the DP Offenhauser, it doesn't necessarily increase the vacuum. The DP design increases air speed at low RPMs, which helps with atomization and your torque. The atomization can also pick up a little gas mileage.
That said, I'm not a fan of the DP and in all my experiences, the open plenum C is just a better design for almost all applications.